Comparative immunogenetics of autism and schizophrenia

  title={Comparative immunogenetics of autism and schizophrenia},
  author={Bernard J. Crespi and Dawn L. Thiselton},
Autism and schizophrenia are highly heritable neurodevelopmental disorders, each mediated by a diverse suite of genetic and environmental risk factors. Comorbidity and familial aggregation of such neurodevelopmental disorders with other disease‐related conditions can provide important insights into their etiology. Epidemiological studies have documented reduced rates of rheumatoid arthritis, a systemic autoimmune condition, in schizophrenia, and recent work has shown increased rates of… 

Immune system gene dysregulation in autism and schizophrenia

The converging evidence strongly argues that neurodevelopmental immune insults and genetic background critically interact and result in increased risk for either autism or schizophrenia.

Immunological and autoimmune considerations of Autism Spectrum Disorders.

Variation in the major histocompatibility complex [MHC] gene family in schizophrenia: Associations and functional implications

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This narrative review was to present up-to-date evidence on cytokine dysregulation in schizophrenia, its effect on the psychopathological presentation, and links with antipsychotic medication, and attempted to summarize its postulated underpinnings.

Immune dysregulation in autism spectrum disorder.

  • E. Hsiao
  • Psychology, Biology
    International review of neurobiology
  • 2013

Microbial "Old Friends", Immunoregulation and Psychiatric Disorders

It is suggested that there are underlying mechanisms, many involving the gut microbiota, that are relevant to all these disorders and that transcend the boundaries between traditional medical disciplines.

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Findings implicating the MHC region are consistent with an immune component to schizophrenia risk, whereas the association with NRGN and TCF4 points to perturbation of pathways involved in brain development, memory and cognition.

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An increased number of autoimmune disorders suggests that in some families with autism, immune dysfunction could interact with various environmental factors to play a role in autism pathogenesis.

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A greater understanding of human genetics, combined with advances in molecular technology has revolutionised the identification of RA-associated genes and will provide crucial information for unravelling the pathogenic disease networks and elucidating potential targets for novel RA therapies.

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Schizophrenia is associated with a larger range of autoimmune diseases than heretofore suspected and future research on comorbidity has the potential to advance understanding of pathogenesis of both psychiatric and autoimmune disorders.

New findings in the genetics of major psychoses

This review summarizes recent developments in genetic research into schizophrenia and bipolar disorder, and discusses possible future directions in this field.

HLA-DR4 in families with autism.

Immune dysfunction in autism: A pathway to treatment

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It is possible that schizophrenia and rheumatoid arthritis share a common infectious and/or immune etiology and that once a person gets one of the diseases then they are relatively immune to the other.

Association of Family History of Autoimmune Diseases and Autism Spectrum Disorders

The observed associations between familial autoimmunity and ASDs/infantile autism are probably attributable to a combination of a common genetic background and a possible prenatal antibody exposure or alteration in fetal environment during pregnancy.