Comparative human oral clinical pharmacology of cefadroxil, cephalexin, and cephradine

  title={Comparative human oral clinical pharmacology of cefadroxil, cephalexin, and cephradine},
  author={Dr. M. Pfeffer and Dr. A. Jackson and Dr. J. Ximenes and Dr. J. Perche de Menezes},
At equivalent oral doses, cefadroxil has a longer serum half-life, slower urinary excretion rate, greater area under the serum level versus time curve than cephalexin or cephadrine, and peak serum concentrations that are 75 to 80% those of cephalexin. The calculated, apparent in vivo volume of distribution of cefadroxil is greater than that of cephalexin. These properties infer greater persistence of cefadroxil in serum und urine and more prolonged in vivo bacterial exposure to cefadroxil than… CONTINUE READING


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