Comparative high-resolution analysis of linkage disequilibrium and tag single nucleotide polymorphisms between populations in the vitamin D receptor gene.

@article{Nejentsev2004ComparativeHA,
  title={Comparative high-resolution analysis of linkage disequilibrium and tag single nucleotide polymorphisms between populations in the vitamin D receptor gene.},
  author={Sergey Nejentsev and Lisa Godfrey and Hywel Snook and Helen E. Rance and Sarah L Nutland and Neil M. Walker and Alex C. Lam and Cristian Guja and Constantin Ionescu-T{\^i}rgovişte and Dag Erik Undlien and Kjersti S R\onningen and Eva Tuomilehto-Wolf and Jaakko Tuomilehto and Melanie J. Newport and David G. Clayton and John A. Todd},
  journal={Human molecular genetics},
  year={2004},
  volume={13 15},
  pages={1633-9}
}
A genome-wide map of single nucleotide polymorphisms (SNP) and a pattern of linkage disequilibrium (LD) between their alleles are being established in three main ethnic groups. An important question is the applicability of such maps to different populations within a main ethnic group. Therefore, we have developed high-resolution SNP, haplotype and LD maps of vitamin D receptor gene region in large samples from five populations. Comparative analysis reveals that the LD patterns are identical in… CONTINUE READING

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