Comparative glycomics of connective tissue glycosaminoglycans.

  title={Comparative glycomics of connective tissue glycosaminoglycans.},
  author={Alicia M Hitchcock and Karen E. Yates and Catherine E. Costello and Joseph Zaia},
  volume={8 7},
Homeostasis of connective joint tissues depends on the maintenance of an extracellular matrix, consisting of an integrated assembly of collagens, glycoproteins, proteoglycans, and glycosaminoglycans (GAGs). Isomeric chondroitin sulfate (CS) glycoforms differing in position and degree of sulfation and uronic acid epimerization play specific and distinct functional roles during development and disease onset. This work profiles the CS epitopes expressed by different joint tissues as a function of… CONTINUE READING


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