Comparative genotoxicity of nanosilver in human liver HepG2 and colon Caco2 cells evaluated by fluorescent microscopy of cytochalasin B-blocked micronucleus formation.

@article{Sahu2014ComparativeGO,
  title={Comparative genotoxicity of nanosilver in human liver HepG2 and colon Caco2 cells evaluated by fluorescent microscopy of cytochalasin B-blocked micronucleus formation.},
  author={Saura C. Sahu and Shambhu Roy and Jiwen Zheng and Jeffrey J. Yourick and Robert L. Sprando},
  journal={Journal of applied toxicology : JAT},
  year={2014},
  volume={34 11},
  pages={1200-8}
}
As a consequence of the increased use of silver nanoparticles in food, food contact materials, dietary supplements and cosmetics to prevent fungal and bacterial growth, there is a need for validated rapid screening methods to assess the safety of nanoparticle exposure. This study evaluated two widely used in vitro cell culture models, human liver HepG2 cells and human colon Caco2 cells, as tools for assessing the potential genotoxicity of 20-nm nanosilver. The average silver nanoparticle size… CONTINUE READING