Comparative genomics of an IncA/C multidrug resistance plasmid from Escherichia coli and Klebsiella isolates from intensive care unit patients and the utility of whole-genome sequencing in health care settings.

@article{Hazen2014ComparativeGO,
  title={Comparative genomics of an IncA/C multidrug resistance plasmid from Escherichia coli and Klebsiella isolates from intensive care unit patients and the utility of whole-genome sequencing in health care settings.},
  author={Tracy H. Hazen and Licheng Zhao and Mallory A Boutin and Angela Stancil and Gwen L Robinson and Anthony D. Harris and David A. Rasko and Jennifer K Johnson},
  journal={Antimicrobial agents and chemotherapy},
  year={2014},
  volume={58 8},
  pages={4814-25}
}
The IncA/C plasmids have been implicated for their role in the dissemination of β-lactamases, including gene variants that confer resistance to expanded-spectrum cephalosporins, which are often the treatment of last resort against multidrug-resistant, hospital-associated pathogens. A bla(FOX-5) gene was detected in 14 Escherichia coli and 16 Klebsiella… CONTINUE READING