Comparative genomics identifies genes mediating cardiotoxicity in the embryonic zebrafish heart.


Retinoic acid (RA) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) activate distinct ligand-dependent transcription factors, and both cause cardiac malformation and heart failure in zebrafish embryos. We hypothesized that they cause this response by hyperactivating a common set of genes critical for heart development. To test this, we used microarrays to… (More)
DOI: 10.1152/physiolgenomics.00214.2007


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