Comparative genomics and transcriptome analysis of Aspergillus niger and metabolic engineering for citrate production

@article{Yin2017ComparativeGA,
  title={Comparative genomics and transcriptome analysis of Aspergillus niger and metabolic engineering for citrate production},
  author={Xian Yin and Hyun-dong Shin and Jianghua Li and Guocheng Du and Long Liu and Jian Chen},
  journal={Scientific Reports},
  year={2017},
  volume={7}
}
Despite a long and successful history of citrate production in Aspergillus niger, the molecular mechanism of citrate accumulation is only partially understood. In this study, we used comparative genomics and transcriptome analysis of citrate-producing strains—namely, A. niger H915-1 (citrate titer: 157 g L−1), A1 (117 g L−1), and L2 (76 g L−1)—to gain a genome-wide view of the mechanism of citrate accumulation. Compared with A. niger A1 and L2, A. niger H915-1 contained 92 mutated genes… Expand
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TLDR
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