Comparative genomics: From genotype to disease phenotype in the leishmaniases

@inproceedings{Smith2007ComparativeGF,
  title={Comparative genomics: From genotype to disease phenotype in the leishmaniases},
  author={Deborah F. Smith and Christopher Sean Peacock and Angela Kaysel Cruz},
  booktitle={International journal for parasitology},
  year={2007}
}
Recent progress in sequencing the genomes of several Leishmania species, causative agents of cutaneous, mucocutaneous and visceral leishmaniasis, is revealing unusual features of potential relevance to parasite virulence and pathogenesis in the host. While the genomes of Leishmania major, Leishmania braziliensis and Leishmania infantum are highly similar in content and organisation, species-specific genes and mechanisms distinguish one from another. In particular, the presence of… CONTINUE READING