Comparative genomics, evolution and origins of the nuclear envelope and nuclear pore complex.

@article{Mans2004ComparativeGE,
  title={Comparative genomics, evolution and origins of the nuclear envelope and nuclear pore complex.},
  author={Ben J. Mans and Vivek Anantharaman and L. Aravind and Eugene V. Koonin},
  journal={Cell cycle},
  year={2004},
  volume={3 12},
  pages={1612-37}
}
The presence of a distinct nucleus, the compartment for confining the genome, transcription and RNA maturation, is a central (and eponymous) feature that distinguishes eukaryotes from prokaryotes. Structural integrity of the nucleus is maintained by the nuclear envelope (NE). A crucial element of this structure is the nuclear pore complex (NPC), a macromolecular machine with over 90 protein components, which mediates nucleo-cytoplasmic communication. We investigated the provenance of the… CONTINUE READING
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