Comparative genomic hybridization analysis in adult T-cell leukemia/lymphoma: correlation with clinical course.

@article{Tsukasaki2001ComparativeGH,
  title={Comparative genomic hybridization analysis in adult T-cell leukemia/lymphoma: correlation with clinical course.},
  author={Kunihiro Tsukasaki and Joseph F Krebs and Kozo Nagai and Masao Tomonaga and H Phillip Koeffler and Claus Rainer Bartram and Anna Jauch},
  journal={Blood},
  year={2001},
  volume={97 12},
  pages={3875-81}
}
Sixty-four patients with adult T-cell leukemia/lymphoma (ATL; 18 patients with indolent subtype and 46 with aggressive subtype) associated with human T-lymphotropic virus type 1 (HTLV-1) were analyzed using comparative genomic hybridization (CGH). The most frequent observations were gains at chromosomes 14q, 7q, and 3p and losses at chromosomes 6q and 13q. Chromosome imbalances, losses, and gains were more frequently observed in aggressive ATL than in indolent ATL, with significant differences… CONTINUE READING