Comparative genomic hybridisation divides retinoblastomas into a high and a low level chromosomal instability group.

@article{Wal2003ComparativeGH,
  title={Comparative genomic hybridisation divides retinoblastomas into a high and a low level chromosomal instability group.},
  author={Jacqueline E van der Wal and Mario A Hermsen and Hans J. P. Gille and Netteke Y N Schouten-van Meeteren and Annette C Moll and Saskia M. Imhof and Gerrit A. Meijer and Jan P. A. Baak and Paul Dlpm van der Valk},
  journal={Journal of clinical pathology},
  year={2003},
  volume={56 1},
  pages={
          26-30
        }
}
BACKGROUND Retinoblastoma is the most common intraocular malignancy in childhood and is responsible for approximately 1% of all deaths caused by childhood cancer. AIMS/METHODS Comparative genomic hybridisation was performed on 13 consecutive, histologically confirmed retinoblastomas to analyse patterns of chromosomal changes and correlate these to clinicopathological variables. Six cases were hereditary and seven cases were sporadic. RESULTS In 11 of the 13 tumours chromosomal abnormalities… CONTINUE READING

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