Comparative genomic analysis of the clade B serpin cluster at human chromosome 18q21: amplification within the mouse squamous cell carcinoma antigen gene locus.

@article{Askew2004ComparativeGA,
  title={Comparative genomic analysis of the clade B serpin cluster at human chromosome 18q21: amplification within the mouse squamous cell carcinoma antigen gene locus.},
  author={David J. Askew and Yuko S. Askew and Yukari Kato and Russell F Turner and Ken Dewar and Jessica Lehoczky and Gary A. Silverman},
  journal={Genomics},
  year={2004},
  volume={84 1},
  pages={176-84}
}
The human clade B serpins neutralize serine or cysteine proteinases and reside predominantly within the intracellular compartment. Genomic analysis shows that the 13 human clade B serpins map to either 6p25 (n = 3) or 18q21 (n = 10). Similarly, the mouse clade B serpins map to syntenic loci at 13A3.2 and 1D, respectively. The mouse clade B cluster at 13A3.2 shows a marked expansion in the number of serpin genes (n = 15). The purpose of this study was to determine whether a similar expansion… CONTINUE READING

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