Comparative genomic analysis of Lactobacillus rhamnosus GG reveals pili containing a human- mucus binding protein.

@article{Kankainen2009ComparativeGA,
  title={Comparative genomic analysis of Lactobacillus rhamnosus GG reveals pili containing a human- mucus binding protein.},
  author={Matti Kankainen and Lars Paul{\'i}n and Soile Tynkkynen and Ingemar von Ossowski and Justus Reunanen and Pasi Partanen and Reetta Satokari and Satu Vesterlund and Antoni P A Hendrickx and Sarah Lebeer and Sigrid C. J. De Keersmaecker and Jozef Vanderleyden and Tuula M. H{\"a}m{\"a}l{\"a}inen and Suvi Laukkanen and Noora Salovuori and Jarmo Ritari and Edward R Alatalo and Riitta Korpela and Tiina Mattila-Sandholm and Anna R Lassig and Katja Hatakka and Katri T Kinnunen and Heli Karjalainen and Maija Saxelin and Kati Laakso and Anu Surakka and Airi M Palva and Tuomas Salusj{\"a}rvi and Petri Auvinen and Willem M de Vos},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2009},
  volume={106 40},
  pages={
          17193-8
        }
}
To unravel the biological function of the widely used probiotic bacterium Lactobacillus rhamnosus GG, we compared its 3.0-Mbp genome sequence with the similarly sized genome of L. rhamnosus LC705, an adjunct starter culture exhibiting reduced binding to mucus. Both genomes demonstrated high sequence identity and synteny. However, for both strains, genomic islands, 5 in GG and 4 in LC705, punctuated the colinearity. A significant number of strain-specific genes were predicted in these islands… CONTINUE READING

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