Comparative genome-scale metabolic modeling of actinomycetes: the topology of essential core metabolism.

@article{Alam2011ComparativeGM,
  title={Comparative genome-scale metabolic modeling of actinomycetes: the topology of essential core metabolism.},
  author={Mohammad Tauqeer Alam and Marnix H. Medema and Eriko Takano and Rainer Breitling},
  journal={FEBS letters},
  year={2011},
  volume={585 14},
  pages={2389-94}
}
Actinomycetes are highly important bacteria. On one hand, some of them cause severe human and plant diseases, on the other hand, many species are known for their ability to produce antibiotics. Here we report the results of a comparative analysis of genome-scale metabolic models of 37 species of actinomycetes. Based on in silico knockouts we generated topological and genomic maps for each organism. Combining the collection of genome-wide models, we constructed a global enzyme association… CONTINUE READING

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