Comparative genome and phenotypic analysis of Clostridium difficile 027 strains provides insight into the evolution of a hypervirulent bacterium

@article{Stabler2009ComparativeGA,
  title={Comparative genome and phenotypic analysis of Clostridium difficile 027 strains provides insight into the evolution of a hypervirulent bacterium},
  author={Richard A Stabler and Miao He and Lisa F. Dawson and Melissa J. Martin and Esmeralda Valiente and Craig H. Corton and Trevor D. Lawley and Mohammed Sebaihia and Michael A. Quail and Graham Rose and Dale N. Gerding and Maryse Gibert and Michel Robert Popoff and Julian Parkhill and Gordon Dougan and Brendan W. Wren},
  journal={Genome Biology},
  year={2009},
  volume={10},
  pages={R102 - R102}
}
The continued rise of Clostridium difficile infections worldwide has been accompanied by the rapid emergence of a highly virulent clone designated PCR-ribotype 027. To understand more about the evolution of this virulent clone, we made a three-way genomic and phenotypic comparison of an 'historic' non-epidemic 027 C. difficile (CD196), a recent epidemic and hypervirulent 027 (R20291) and a previously sequenced PCR-ribotype 012 strain (630). Although the genomes are highly conserved, the 027… CONTINUE READING
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