Comparative genetic study of intratumoral heterogenous MYCN amplified neuroblastoma versus aggressive genetic profile neuroblastic tumors

@article{Berbegall2016ComparativeGS,
  title={Comparative genetic study of intratumoral heterogenous MYCN amplified neuroblastoma versus aggressive genetic profile neuroblastic tumors},
  author={Ana P. Berbegall and Eva Villam{\'o}n and Marta Piqueras and Irene Tadeo and Anna Djos and Peter F. Ambros and Tommy Martinsson and Inge M. Ambros and Adela Ca{\~n}ete and Victoria Castel and Samuel Navarro and Rosa Noguera},
  journal={Oncogene},
  year={2016},
  volume={35},
  pages={1423-1432}
}
Intratumoral heterogeneous MYCN amplification (hetMNA) is an unusual event in neuroblastoma with unascertained biological and clinical implications. Diagnosis is based on the detection of MYCN amplification surrounded by non-amplified tumor cells by fluorescence in situ hybridization (FISH). To better define the genetic features of hetMNA tumors, we studied the Spanish cohort of neuroblastic tumors by FISH and single nucleotide polymorphism arrays. We compared hetMNA tumors with homogeneous MNA… CONTINUE READING