Comparative gene expression profiling analysis of lymphoblastoid cells reveals neuron-specific enolase gene (ENO2) as a susceptibility gene of heroin dependence.

@article{Liao2014ComparativeGE,
  title={Comparative gene expression profiling analysis of lymphoblastoid cells reveals neuron-specific enolase gene (ENO2) as a susceptibility gene of heroin dependence.},
  author={Ding-Lieh Liao and Min-Chih Cheng and Chih-Hao Lai and Hui-Ju Tsai and Chia-Hsiang Chen},
  journal={Addiction biology},
  year={2014},
  volume={19 1},
  pages={102-10}
}
Heroin dependence is a complex mental disorder resulting from interactions between genetic and environmental factors. Identifying the susceptibility genes of heroin dependence is the basis for understanding the pathogenesis of heroin dependence. Using a total gene expression microarray, we detected 924 differentially expressed gene transcripts in lymphoblastoid cell lines (LCLs) between 19 male heroin-dependent individuals and 20 male control subjects, including 279 upregulated and 645… CONTINUE READING