Comparative fitness assessment of Anopheles stephensi transgenic lines receptive to site-specific integration.

@article{Amenya2010ComparativeFA,
  title={Comparative fitness assessment of Anopheles stephensi transgenic lines receptive to site-specific integration.},
  author={Dolphine A Amenya and Mariangela Bonizzoni and Alison T Isaacs and Nijole Jasinskiene and Haotong Chen and Osvaldo Marinotti and Guang-Rong Yan and Anthony A. James},
  journal={Insect molecular biology},
  year={2010},
  volume={19 2},
  pages={
          263-9
        }
}
Genetically modified mosquitoes that are unable to transmit pathogens offer opportunities for controlling vector-borne diseases such as malaria and dengue. Site-specific gene recombination technologies are advantageous in the development of these insects because antipathogen effector genes can be inserted at integration sites in the genome that cause the least alteration in mosquito fitness. Here we describe Anopheles stephensi transgenic lines containing phi C31 attP'docking' sites linked to a… CONTINUE READING

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