Comparative expressed-sequence-tag analysis of differential gene expression profiles in PC-12 cells before and after nerve growth factor treatment.

@article{Lee1995ComparativeEA,
  title={Comparative expressed-sequence-tag analysis of differential gene expression profiles in PC-12 cells before and after nerve growth factor treatment.},
  author={Norman H. Lee and Keith Weinstock and Ewen F. Kirkness and Julie Earle-Hughes and R A Fuldner and S Marmaros and Aleksandra Glodek and Jeannine D. Gocayne and Mark D Adams and Anthony R. Kerlavage},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1995},
  volume={92 18},
  pages={8303-7}
}
Nerve growth factor-induced differentiation of adrenal chromaffin PC-12 cells to a neuronal phenotype involves alterations in gene expression and represents a model system to study neuronal differentiation. We have used the expressed-sequence-tag approach to identify approximately 600 differentially expressed mRNAs in untreated and nerve growth factor-treated PC-12 cells that encode proteins with diverse structural and biochemical functions. Many of these mRNAs encode proteins belonging to… CONTINUE READING

From This Paper

Topics from this paper.
52 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 52 extracted citations

Similar Papers

Loading similar papers…