Comparative experimental investigation of the anabolic activity of phytoecdysteroids and steranabols

  title={Comparative experimental investigation of the anabolic activity of phytoecdysteroids and steranabols},
  author={Vladimir Nikolayevich Syrov},
  journal={Pharmaceutical Chemistry Journal},
  • V. Syrov
  • Published 1 April 2000
  • Biology
  • Pharmaceutical Chemistry Journal
Many compounds originally isolated from plants have been used since ancient times as drugs. Among the classes of natural substances isolated relatively recently, of special interest are the so-called phytoecdysteroids. These compounds, structurally close or identical to the hormones of ecdysis (molting) and metamorphosis in insects, were found to be capable of activating protein biosynthesis in of mammals [1]. However, these drugs were not studied with respect to their possible anabolizing… 

Phytoecdysteroids: understanding their anabolic activity

Phytoecdysteroids, polyhydroxylated ketosteroids, are the plant analogues of insect growth hormones, although their role in insect molting is well characterized, their function in plants is less clear.

Phytoecdysteroids-containing extract from Stachys hissarica plant and its wound-healing activity

The wound-healing activity of S. hissarica extract is confirmed to be effective and exceeds known drug methyluracil, especially in case of alloxan induced diabetic animals.

Ethnopharmacology of the plants of genus Ajuga.

Members of the genus Ajuga have been used in traditional medicine as a remedy for fever, toothache, dysentery, malaria, high blood pressure, diabetes, gastrointestinal disorders, as anthelmintic, diuretic and antifungal, anti-inflammatory, and antimycobacterial agents and are also used as insect growth inhibitor s.

Ecdysteroids: A novel class of anabolic agents?

Molecular docking experiments supported the ERβ mediated action of ecdysterone and should be considered to be included in the class “S1.2 Other Anabolic Agents” of the list of prohibited substances of the World Anti-Doping Agency.

Phytoecdysteroids from Silene plants: distribution, diversity and biological (antitumour, antibacterial and antioxidant) activities

The biological (antitumour, antibacterial and antioxidant) activities and the phytoecdysteroids of genus Silene are reviewed and the folk and traditional effects of Silene plants are reported on.

Comparison between the Biological Active Compounds in Plants with Adaptogenic Properties (Rhaponticum carthamoides, Lepidium meyenii, Eleutherococcus senticosus and Panax ginseng)

There is great potential in the near future for some of the phytochemicals found in these plants species to become pharmaceutical agents.

20-Hydroxyecdysone’s Cyclodextrin Complex: A Novel Anabolic Phytosteroid (APS)?

20-HE’s pharmacodynamics and pharmacokinetics are explored, with a particular interest on how the 20- HE-CD complex can improve the oral bioavailability of 20-HE, making 20-he-CD a novel anabolic phytosteroid (APS).

Preparative-scale chromatography of ecdysteroids: a class of biologically active steroids.

The preparative-scale separation work results in a minor, as yet unknown ecdysteroid, which is readily available for insect physiology experiments and for structure-activity relationship studies.

Ecdysterone and its Activity on some Degenerative Diseases

Because of the possibility of suppression of neurodegenerative processes and protection of the cardiovascular system, ecdysterone has the potential to be developed as a medicinal agent.



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