Comparative studies of the protective effect of Alupent and Th 1165a against histamine in man.
- H M Beumer
- Respiration; international review of thoracic…
The broncholytic effect of inhaled atropine, isoprotenerol and orciprenaline and that of intravenously administered atropine was observed for one hour in ten patients suffering from chronic obstructive bronchitis. With the dosages and modes of administration employed, all drugs examined reduced the values of total airway resistance and intrathoracic gas volume to the same extent. Compared with the other preparations, the effect of orciprenaline was delayed in respect of specific conductance. The broncholytic potency of all substances examined was found to be dependent on the pretreatment value so that the “Law of Initial Value” — established in respect of blood circulation — seems to be valid in respect of the bronchial system as well. The present investigations justify the conclusion that a dysfunction of the autonomic nervous system (manifesting itself in intensified cholinergic activity is an important pathogenic factor in chronic obstructive bronchitis.