Comparative evaluation of tigecycline and vancomycin, with and without rifampicin, in the treatment of methicillin-resistant Staphylococcus aureus experimental osteomyelitis in a rabbit model.

@article{Yin2005ComparativeEO,
  title={Comparative evaluation of tigecycline and vancomycin, with and without rifampicin, in the treatment of methicillin-resistant Staphylococcus aureus experimental osteomyelitis in a rabbit model.},
  author={Li-yan Yin and Luca Lazzarini and Fan Yang Li and Curtis. Stevens and Jason H. Calhoun},
  journal={The Journal of antimicrobial chemotherapy},
  year={2005},
  volume={55 6},
  pages={
          995-1002
        }
}
OBJECTIVES Staphylococcus aureus is the most common organism isolated in osteomyelitis. Methicillin-resistant S. aureus (MRSA) infections are particularly difficult to treat. We evaluated the efficacy of tigecycline and vancomycin with and without rifampicin in a rabbit model of MRSA osteomyelitis. METHODS A 28 day antibiotic therapy with a subcutaneous injection of tigecycline (14 mg/kg twice daily), with and without oral rifampicin (40 mg/kg twice daily); or subcutaneous administration of… CONTINUE READING
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