Comparative evaluation of the My5-FU™ immunoassay and LC-MS/MS in monitoring the 5-fluorouracil plasma levels in cancer patients.

@article{Bchel2013ComparativeEO,
  title={Comparative evaluation of the My5-FU™ immunoassay and LC-MS/MS in monitoring the 5-fluorouracil plasma levels in cancer patients.},
  author={Barbara B{\"u}chel and Johanna Sistonen and Markus Joerger and Yolanda Aebi and Stefan Sch{\"u}rch and Carlo R. Largiad{\`e}r},
  journal={Clinical chemistry and laboratory medicine},
  year={2013},
  volume={51 8},
  pages={
          1681-8
        }
}
BACKGROUND Chemotherapies of solid tumors commonly include 5-fluorouracil (5-FU). With standard doses of 5-FU, substantial inter-patient variability has been observed in exposure levels and treatment response. Recently, improved outcomes in colorectal cancer patients due to pharmacokinetically guided 5-FU dosing were reported. We aimed at establishing a rapid and sensitive method for monitoring 5-FU plasma levels in cancer patients in our routine clinical practice. METHODS Performance of the… CONTINUE READING
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