Comparative evaluation of plastic, hydrophobic and hydrophilic polymers as matrices for controlled-release drug delivery.

@article{Reza2003ComparativeEO,
  title={Comparative evaluation of plastic, hydrophobic and hydrophilic polymers as matrices for controlled-release drug delivery.},
  author={M D Selim Reza and Mohiuddin Abdul Quadir and Syed Shabbir Haider},
  journal={Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques},
  year={2003},
  volume={6 2},
  pages={282-91}
}
PURPOSE The present study was undertaken to investigate the effect of plastic, hydrophilic and hydrophobic types of polymers and their content level on the release profile of drug from matrix systems. As the physico-chemical nature of the active ingredients influence the drug retarding ability of these polymers, three different drugs were used to evaluate their comparative release characteristics in similar matrices. METHODS Matrix tablets of theophylline, diclofenac sodium and diltiazem HCl… CONTINUE READING