• Corpus ID: 24537940

Comparative evaluation of in vitro cytotoxic effects among parent abietyl alcohol and novel fatty acid ester derivatives against MCF7 and hepatocellular carcinoma cell lines.

  title={Comparative evaluation of in vitro cytotoxic effects among parent abietyl alcohol and novel fatty acid ester derivatives against MCF7 and hepatocellular carcinoma cell lines.},
  author={Muhammad Ayaz Mustufa and Afshan Aslam and Cigdem Ozen and Imran Ali Hashmi and Naimul Hasan Naqvi and Mehmet Ozturk and Firdous Imran Ali},
  journal={Pakistan journal of pharmaceutical sciences},
  volume={27 6 Suppl},
Synthesis of twelve hitherto unreported esters of abietyl alcohol and screening of these esters against four cancer cell lines including one breast cancer line MCF7 and four hepatocellular carcinoma cell lines (HCC) Huh7, Hep3B, Snu449 and Plc has been determined using SRB assay. The Cell cycle progression showed changes in cellular behaviour after 48 and 72 hours in MCF7 and Huh7 cell lines. Abietyl alcohol was obtained from the reduction of abietic acid, a tricyclic diterpene, isolated from… 


Synthesis and characterization of amino acid conjugates of oleanolic acid and their in vitro cytotoxic effect on HCC cell lines.
Cytotoxic effects revealed that as compare to parent compound (OA-01), two derivatives OA-04 and OA -06 showed significantly increased/higher inhibition rates, and four known and two new C-28 amino acid conjugates of oleanolic acid were prepared to explore potential of these compounds on HCCs and one breast cancer cell line.
Synthesis and biological evaluation of abietic acid derivatives.
A series of C18-oxygenated derivatives of abietic acid were synthesized and evaluated for their cytotoxic, antimycotic, and antiviral activities. In general, the introduction of an aldehyde group at
Synthesis and antitumor activity of novel a-aminophosphonates from diterpenic dehydroabietylamine
A series of novel α-aminophosphonates were synthesized from diterpenic dehydroabietylamine, and their structures were characterized by IR, 1H NMR, and 31P NMR spectroscopy. Their antitumor activities
Anti-tumor abietane diterpenes from the cones of Sequoia sempervirens.
A new abietane, namely, 20-hydroxyferruginol was isolated from the cones of Sequoia sempervirens and strongly inhibited colon, lung, and breast human tumors and oncogene transformed cells with GI 2-5 microg/mL.
Antitumour lignans and cytotoxic resin acids from a New Zealand gymnosperm, Libocedrus plumosa.
  • N. B. Perry, L. M. Foster
  • Biology, Medicine
    Phytomedicine : international journal of phytotherapy and phytopharmacology
  • 1994
Chemical screening and mass spectroscopy results for the two Libocedrus species and for Cupressus macrocarpa suggested that the P388 activity of the latter species was also due to β-peltatin 1 and 2, and extracts of all three of these species inhibited tubulin polymerisation.
Sulforhodamine B colorimetric assay for cytotoxicity screening
The sulforhodamine B (SRB) assay is used for cell density determination, based on the measurement of cellular protein content, which is an efficient and highly cost-effective method for screening.
Egyptian Propolis: 2. Chemical Composition, Antiviral And Antimicrobial Activities Of East Nile Delta Propolis
Three propolis samples from East Nile Delta, Egypt were collected and Dakahlia propolis showed the highest antiviral activity against Infectious Bursal Disease Virus (IBDV) and the highest antibacterial activity against Escherichia coli and thehighest antifungal activity against Candida albicans, while Ismailia Propolis had the highest Antimicrobial activity against Reo-virus.
Antiulcer activity of dehydroabietic acid derivatives.
On prepare une serie de derives de l'acide deshydroabietique avec un groupement hydrophile (amino, carbamoyl, carbamoyloxy, ureido, sulfamoyl, ou sulfo) sur les positions 12 et/ou 18 et on teste leur
Synthesis of (+)-amberketal and its analog from l-abietic acid
Abstract (+)-Amberketal ( 1 ) and its analog ( 2 ) have been synthesized from commercially available l -abietic acid ( 3 ) by a selective reduction of an unsaturated aldehyde in the presence of a
A mild and efficient method for esterification and transesterification catalyzed by iodine
Iodine, was found to be a practical and useful Lewis acid catalyst for the esterification of carboxylic acids with alcohols. The high catalytic activity of iodine can be used for the