Comparative enantioselectivity in the sulphoxidation of albendazole in man, dogs and rats.

@article{Delatour1991ComparativeEI,
  title={Comparative enantioselectivity in the sulphoxidation of albendazole in man, dogs and rats.},
  author={Paul Delatour and Etienne Beno{\^i}t and St{\'e}phane Besse and A Boukraa},
  journal={Xenobiotica; the fate of foreign compounds in biological systems},
  year={1991},
  volume={21 2},
  pages={217-21}
}
1. H.p.l.c. analyses were performed to investigate the plasma kinetics of albendazole (ABZ), the sulphoxide (SO.ABZ) and sulphone (SO2ABZ) metabolites, as well as the chirality vs time of SO.ABZ, after oral administration to rats, dogs and man of prochiral sulphide antiparasitic drug ABZ. 2. In all three species the initial plasma concentration ratio of the enantiomers, as soon as SO.ABZ could be detected in plasma, was that of a racemate. 3. Subsequently, the ratio (+)/(-) increased linearly… CONTINUE READING

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