Comparative efficacy of pharmacological interventions for contrast-induced nephropathy prevention after coronary angiography: a network meta-analysis from randomized trials

  title={Comparative efficacy of pharmacological interventions for contrast-induced nephropathy prevention after coronary angiography: a network meta-analysis from randomized trials},
  author={Wen-Qi Ma and Yu Zhao and Ying Wang and Xiqiong Han and Yi Zhu and Naifeng Liu},
  journal={International Urology and Nephrology},
  • W. Ma, Yu Zhao, Naifeng Liu
  • Published 5 February 2018
  • Medicine, Biology
  • International Urology and Nephrology
BackgroundContrast-induced nephropathy (CIN) is the major complication related to contrast media administration in patients after coronary angiography (CAG). However, inconsistent results have been published in the literature regarding the effects of pharmacological drugs on CIN prevention. We conducted a network meta-analysis to evaluate the relative efficacy of pharmacological interventions for the prevention of CIN.MethodsWe searched MEDLINE, EMBASE, Cochrane Central Register of Controlled… 
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Successful management of AKI in patients with an injured brain requires an in-depth understanding of the fluid and electrolyte homeostasis, as well as appropriate modifications of RRT in the acute setting.


Contrast-induced nephropathy following angiography and cardiac interventions
The widespread adoption of primary PCI for the treatment of acute myocardial infarction (AMI), despite significantly improving cardiovascular outcomes, has increased the incidence of CIN due to the inherent difficulties in rapidly assessing CIN.
Outcomes of contrast‐induced nephropathy: Experience in patients undergoing cardiovascular intervention
  • P. McCullough
  • Medicine
    Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions
  • 2006
Precautionary measures before, during, and after the use of Contrast media that reduce the incidence of CIN, such as discontinuation of nephrotoxic medications, adequate hydration, and use of appropriate volumes and types of contrast media, should be considered in all patients with renal insufficiency or with other risk factors for CIN.
Prevention of contrast-induced AKI: a review of published trials and the design of the prevention of serious adverse events following angiography (PRESERVE) trial.
Key methodological issues of past trials investigating IV fluids and NAC are discussed and how they informed the design of the PRESERVE trial are discussed.
Randomized Trial of Bicarbonate or Saline Study for the Prevention of Contrast-Induced Nephropathy in Patients with CKD.
High-dose sodium bicarbonate infusion in patients with eGFR<45 ml/min per 1.73 m(2) undergoing angiography did not demonstrate a difference in incidence of the composite of death, dialysis, or sustained 6-month reduction in eG FR or CIAKI compared with sodium chloride.
Iloprost Prevents Contrast-Induced Nephropathy in Patients With Renal Dysfunction Undergoing Coronary Angiography or Intervention
Prophylactic administration of iloprost may protect against contrast-induced nephropathy in high-risk patients undergoing a coronary procedure.
How to prevent contrast-induced nephropathy and manage risk patients: practical recommendations.
All patients receiving contrast should be evaluated for their risk of contrast-induced nephropathy, and adequate, prospective, cohort studies should be conducted to compare the incidence of CIN following intraarterial and i.v. administration of contrast.
Effectiveness of Prevention Strategies for Contrast-Induced Nephropathy
A systematic review and meta-analysis was done to compare the preventive effect of strategies to reduce CIN, including subgroup analyses based on route of administration of contrast media or preventive strategies and the type of Contrast media used.