Comparative efficacy of newer hypnotic drugs for the short‐term management of insomnia: a systematic review and meta‐analysis

@article{Dndar2004ComparativeEO,
  title={Comparative efficacy of newer hypnotic drugs for the short‐term management of insomnia: a systematic review and meta‐analysis},
  author={Yenal D{\"u}ndar and Susanna Dodd and Judith Strobl and Angela Boland and Rumona Dickson and Thomas J Walley},
  journal={Human Psychopharmacology: Clinical and Experimental},
  year={2004},
  volume={19}
}
  • Y. DündarS. Dodd T. Walley
  • Published 1 July 2004
  • Psychology, Medicine
  • Human Psychopharmacology: Clinical and Experimental
To compare the clinical effectiveness of zaleplon, zolpidem or zopiclone (Z‐drugs) with either benzodiazepines licensed and approved for use in the UK for the short‐term management of insomnia (diazepam, loprazolam, lorazepam, lormetazepam, nitrazepam, temazepam) or with each other. 

Suvorexant for insomnia: a systematic review of the efficacy and safety profile for this newly approved hypnotic – what is the number needed to treat, number needed to harm and likelihood to be helped or harmed?

  • L. Citrome
  • Psychology
    International journal of clinical practice
  • 2014
The efficacy and safety of suvorexant for the treatment of insomnia are described and the drug is described as safe and effective.

Management of insomnia: treatments and mechanisms

Current treatments of insomnia are described, both evidence-based and common practice, and some emerging approaches are described.

Comparative efficacy and acceptability of pharmacological treatments for insomnia in adults: A systematic review and network meta-analysis

This work aims to generate a clinically-useful hierarchy of available pharmacological treatments for insomnia in adults, according to their efficacy and acceptability, and to compare individual medications in terms of efficacy and acceptance.

Effectiveness of non-benzodiazepine hypnotics in treatment of adult insomnia: meta-analysis of data submitted to the Food and Drug Administration

Compared with placebo, Z drugs produce slight improvements in subjective and polysomnographic sleep latency, especially with larger doses and regardless of type of drug.

Pharmacologic treatment of insomnia

The Efficacy and Safety of Drug Treatments for Chronic Insomnia in Adults: A Meta-analysis of RCTs

Benzodiazepines and non-benzodiazepine treatments for chronic insomnia are effective treatments in the management of chronic insomnia, although they pose a risk of harm.

A double-blind, randomized, comparative study to evaluate the efficacy and safety of zaleplon versus zolpidem in shortening sleep latency in primary insomnia.

There was no significant difference between zaleplon and zolpidem in the efficacy of reducing sleep latency or adverse effects in primary insomnia, and a large pharmacovigilance study is needed before concluding that either zalpidem or zalplon is free from next-day residual effects.

[Insomnias. II. Pharmacological and psychotherapeutic treatment options].

Cognitive behavioural therapy for insomnia (including psycho-education, relaxation, stimulus control, sleep restriction, cognitive therapy) is supported by an extensive database that indicates that cognitive behavioural methods are effective in the long term, thus emphasizing the importance of these strategies in the treatment of insomnia.
...

References

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  • Psychology, Medicine
    British Journal of Psychiatry
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Zopiclone, a non-benzodiazepine hypnotic, was compared with temazepam in the treatment of 36 patients suffering from insomnia and there were highly significant improvements with both drugs, as compared to the control period in respect of sleep latency, number of times waking during the night, and quality and duration of sleep.

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