Comparative efficacy of newer hypnotic drugs for the short‐term management of insomnia: a systematic review and meta‐analysis

@article{Dndar2004ComparativeEO,
  title={Comparative efficacy of newer hypnotic drugs for the short‐term management of insomnia: a systematic review and meta‐analysis},
  author={Y. D{\"u}ndar and S. Dodd and J. Strobl and A. Boland and R. Dickson and T. Walley},
  journal={Human Psychopharmacology: Clinical and Experimental},
  year={2004},
  volume={19}
}
To compare the clinical effectiveness of zaleplon, zolpidem or zopiclone (Z‐drugs) with either benzodiazepines licensed and approved for use in the UK for the short‐term management of insomnia (diazepam, loprazolam, lorazepam, lormetazepam, nitrazepam, temazepam) or with each other. 
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  • International journal of clinical practice
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TLDR
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TLDR
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TLDR
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References

SHOWING 1-10 OF 32 REFERENCES
Comparison of nitrazepam and zopiclone in psychiatric patients.
TLDR
The results indicate that zopiclone is an active hypnotic compound, comparable in its effects to those of nitrazepam, the higher dosage being best adapted to the type of patients included in the study. Expand
Zopiclone versus nitrazepam: a double-blind comparative study of efficacy and tolerance in elderly patients with chronic insomnia.
TLDR
A randomized, double-blind, comparative trial of zopiclone versus nitrazepam was conducted in 74 geriatric chronic insomniac patients, finding that zopicLone was devoid of effect on neurological function and the condition on awakening was better with zopic lone. Expand
Zopiclone: a non-benzodiazepine hypnotic. Controlled comparison to temazepam in insomnia.
  • D. Wheatley
  • Psychology, Medicine
  • The British journal of psychiatry : the journal of mental science
  • 1985
TLDR
Zopiclone, a non-benzodiazepine hypnotic, was compared with temazepam in the treatment of patients suffering from insomnia and there were highly significant improvements with both drugs, as compared to the control period in respect of: sleep latency, number of times waking during the night, and quality and duration of sleep. Expand
Sleep latency is shortened during 4 weeks of treatment with zaleplon, a novel nonbenzodiazepine hypnotic. Zaleplon Clinical Study Group.
TLDR
Zaleplon appears to provide a favorable safety profile, as indicated by the absence of rebound insomnia and withdrawal symptoms once treatment was discontinued, and was effective in the treatment of insomnia in outpatients with DSM-III-R insomnia. Expand
Double-blind study on the hypnotic and antianxiety effects of zopiclone compared with nitrazepam in the treatment of insomnia.
TLDR
The effectiveness of zopiclone in the treatment of insomnia with effects similar to nitrazepam on the quality and duration of sleep and number of nocturnal arousals, but with an improvement in all the other parameters is confirmed. Expand
Zaleplon, A Novel Nonbenzodiazepine Hypnotic, Effectively Treats Insomnia in Elderly Patients Without Causing Rebound Effects.
TLDR
Zaleplon is effective in reducing latency to sleep without evidence of undesired effects in elderly patients with insomnia, and the frequency of any central nervous system adverse events is unchanged. Expand
Preference of insomniac patients between a single dose of zolpidem 10 mg versus zaleplon 10 mg
TLDR
Insomniac patients tended to prefer zolpidem to zaleplon on both nocturnal and diurnal assessments, and these results provide additional information for the physician's choice, based on the patient's preference for a given drug. Expand
Double‐blind, placebo‐controlled study comparing effects of zopiclone and temazepam on cognitive functioning of insomniacs
The purpose of this study was to compare the cognitive effect of two medications frequently prescribed to patients suffering from insomnia. Using a double‐blind design, we evaluated three parallelExpand
Chronic administration of zopiclone and nitrazepam in the treatment of insomnia.
TLDR
A significant improvement in the working ability of patients was noted with both drugs, and some significant differences were observed in the mood rating scale and the somatic complaint check list, probably related to differences in pharmacokinetics of the two drugs. Expand
Zaleplon improves sleep without producing rebound effects in outpatients with insomnia
TLDR
Results show that zaleplon provides effective treatment of insomnia with a favourable safety profile and a significantly greater incidence of withdrawal symptoms and a suggestion of sleep difficulty after treatment discontinuation was seen with zolpidem compared to placebo. Expand
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