Comparative efficacy of in vitro and in vivo metabolized aspirin in the DeBakey ventricular assist device

@article{Sheriff2013ComparativeEO,
  title={Comparative efficacy of in vitro and in vivo metabolized aspirin in the DeBakey ventricular assist device},
  author={Jawaad Sheriff and Gaurav Girdhar and Wei-Che Chiu and Jolyon Jesty and Marvin J. Slepian and Danny Bluestein},
  journal={Journal of Thrombosis and Thrombolysis},
  year={2013},
  volume={37},
  pages={499-506}
}
Ventricular assist devices (VADs) are implanted in patients with end-stage heart failure to provide both short- and long-term hemodynamic support. Unfortunately, bleeding and thromboembolic complications due to the severely disturbed, dynamic flow conditions generated within these devices require complex, long-term antiplatelet and anticoagulant therapy. While several studies have examined the effectiveness of one such agent, aspirin, under flow conditions, data comparing the efficacy of in… CONTINUE READING