Comparative efficacy and toxicity of desferrioxamine, deferiprone and other iron and aluminium chelating drugs.

@article{Kontoghiorghes1995ComparativeEA,
  title={Comparative efficacy and toxicity of desferrioxamine, deferiprone and other iron and aluminium chelating drugs.},
  author={George J Kontoghiorghes},
  journal={Toxicology letters},
  year={1995},
  volume={80 1-3},
  pages={1-18}
}
The efficacy and toxicity aspects of the iron and aluminium chelating drugs desferrioxamine and deferiprone (L1, 1,2-dimethyl-3-hydroxypyrid-4-one), have been compared. Major emphasis was given in the use of these two and also of other chelators in conditions of iron overload, imbalance and toxicity, as well as the incidence and possible causes of toxic side effects in both animals and humans. The chemical basis of chelation and the interaction of these chelators with the iron pools are… CONTINUE READING

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