Comparative efficacy and acceptability of drug treatments for bipolar depression: a multiple‐treatments meta‐analysis

@article{Taylor2014ComparativeEA,
  title={Comparative efficacy and acceptability of drug treatments for bipolar depression: a multiple‐treatments meta‐analysis},
  author={Demetria M. Taylor and Victoria R. Cornelius and L. A. Smith and A. H. Young},
  journal={Acta Psychiatrica Scandinavica},
  year={2014},
  volume={130}
}
Treatment of bipolar depression is complicated by variable response and risk of switch to mania. Guidance is informed by the strength of evidence rather than by comparative data. 

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References

SHOWING 1-10 OF 70 REFERENCES

Long‐term antidepressant treatment in bipolar disorder: meta‐analyses of benefits and risks

Objective:  Long‐term antidepressant (AD) treatment for depression in bipolar disorder (BPD) patients is highly prevalent, but its benefits and risks remain uncertain, encouraging this meta‐analysis

Celecoxib as an adjunct in the treatment of depressive or mixed episodes of bipolar disorder: a double‐blind, randomized, placebo‐controlled study

TLDR
To investigate whether the cox‐2 inhibitor celecoxib has antidepressant effects in bipolar disorder (BD) patients during depressive or mixed phases, a new drug is developed that combines the former and the latter into a single pill.

Previous mood state predicts response and switch rates in patients with bipolar depression

TLDR
The role for antidepressant (AD) agents vs. mood stabilizers has been particularly problematic to ascertain and this work aims to clarify this role.

Lithium response in unipolar versus bipolar depression.

The antidepressant effects of lithium carbonate were evaluated in a group of 52 hospitalized depressed patients, using a longitudinal double-blind design that involved alternating drug and placebo

The use of lithium in affective disorders. I. Acute endogenous depression.

TLDR
After two to three weeks, there was evidence of a moderate to strong antidepressant effect of imipramine, while lithium produced only a weak to mild antidepressant effect.

Efficacy of olanzapine monotherapy for treatment of bipolar I depression: a randomized, double-blind, placebo controlled study

TLDR
Olanzapine is effective in the treatment of bipolar I depression but is associated with significant metabolic side effects.

Efficacy and safety of lamotrigine as add-on treatment to lithium in bipolar depression: a multicenter, double-blind, placebo-controlled trial.

TLDR
Lamotrigine was found effective and safe as add-on treatment to lithium in the acute treatment of bipolar depression.

Unipolar and bipolar depression: different of the same?

The diagnostic boundary between recurrent unipolar depression and bipolar disorder may not be clear-cut and, further, the symptoms of unipolar depression compared with bipolar depression (although

Lamotrigine in the acute treatment of bipolar depression: results of five double-blind, placebo-controlled clinical trials.

TLDR
Lamotrigine monotherapy did not demonstrate efficacy in the acute treatment of bipolar depression in four out of five placebo-controlled clinical studies, but was well tolerated inThe results of five randomized, double-blind, placebo- controlled trials of lamotrigin monotherapy were reported.
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