Comparative efficacy: what we know, what we need to know, and how we can get there.

@article{Malozowski2008ComparativeEW,
  title={Comparative efficacy: what we know, what we need to know, and how we can get there.},
  author={Saul N. Malozowski},
  journal={Annals of internal medicine},
  year={2008},
  volume={148 9},
  pages={
          702-3
        }
}
In the past decade, the number of medications to treat osteoporosis has markedly increased (1). These drugs have distinct mechanisms of action. However, information on the efficacy of these compounds relative to one another remains limited, which frustrates physicians who want to practice according to the evidence. Some may attribute this gap to the U.S. Food and Drug Administration's regulatory mandate requiring well-controlled studies to assess both efficacy and safety for registration trials… CONTINUE READING
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