Comparative efficacies of rifaximin and vancomycin for treatment of Clostridium difficile-associated diarrhea and prevention of disease recurrence in hamsters.

@article{Kokkotou2008ComparativeEO,
  title={Comparative efficacies of rifaximin and vancomycin for treatment of Clostridium difficile-associated diarrhea and prevention of disease recurrence in hamsters.},
  author={Efi G Kokkotou and Alan C. Moss and A Michos and Daniel G. Espinoza and Jeffrey W Cloud and Nasima Mustafa and Michael O'brien and Charalabos Pothoulakis and Ciaran Kelly},
  journal={Antimicrobial agents and chemotherapy},
  year={2008},
  volume={52 3},
  pages={1121-6}
}
Clostridium difficile-associated colitis is an increasing cause of morbidity and mortality in hospitalized patients, with high relapse rates following conventional therapy. We sought to determine the efficacy of rifaximin, a novel nonabsorbed antibiotic, in the hamster model of C. difficile-associated diarrhea (CDAD). Hamsters received clindamycin subcutaneously and 24 h later were infected by gavage with one of two C. difficile strains: a reference strain (VPI 10463) and a current epidemic… CONTINUE READING