Comparative effects of velnacrine, tacrine and physostigmine on the twitch responses in the rat phrenic-hemidiaphragm preparation.

Abstract

1. Cholinesterase inhibitors potentiated twitch responses induced by nerve stimulation, with physostigmine more potent than tacrine and velnacrine. However, at higher concentrations, tacrine decreased twitch responses in a concentration-dependent manner. 2. Tacrine strongly depressed directly-induced twitch responses, whereas the other drugs had minimal… (More)

Topics

Cite this paper

@article{Bosch1993ComparativeEO, title={Comparative effects of velnacrine, tacrine and physostigmine on the twitch responses in the rat phrenic-hemidiaphragm preparation.}, author={Friedrich Bosch and Marcelino L. Morales and Adri{\`a} Puigdom{\`e}nech Badia and Josep Eladi Ba{\~n}os}, journal={General pharmacology}, year={1993}, volume={24 5}, pages={1101-5} }