Comparative effects of the Roundup and glyphosate on mitochondrial oxidative phosphorylation.

  title={Comparative effects of the Roundup and glyphosate on mitochondrial oxidative phosphorylation.},
  author={Francisco Peixoto},
  volume={61 8},
The potential toxicity of the herbicide Roundup and its fundamental substance (glyphosate) was tested in bioenergetic functions of isolated rat liver mitochondria. Roundup stimulates succinate-supported respiration twice, with simultaneous collapse of transmembrane electrical potential, while glyphosate used in the same concentrations does not induce any significant effect. Additionally, Roundup depresses state 3 respiration by about 40%, at 15 mM, whereas uncoupled respiration in the presence… CONTINUE READING
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