Comparative effects of synthetic enkephalinamides and morphine on abstinence responses in morphine-dependent mice.

  • H. N. Bhargava
  • Published 1980 in Pharmacology, biochemistry, and behavior


The effects of intracerebroventricular (ICV) administration of two synthetic enkephalinamides, D-Ala2-Met5-enkephalinamide and D-Met2-Pro5-enkephalinamide, were compared with those of morphine on abstinence responses in morphine dependent mice. Mice were rendered dependent by morphine pellet implantation for three days. When administered six hours after… (More)


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