Comparative effects of novel 5-HT1A receptor ligands, LY293284, LY315712 and LY297996, on plus-maze anxiety in mice

  title={Comparative effects of novel 5-HT1A receptor ligands, LY293284, LY315712 and LY297996, on plus-maze anxiety in mice},
  author={B J Cao and R. John Rodgers},
  • B. Cao, R. Rodgers
  • Published 9 September 1998
  • Biology, Psychology
  • Psychopharmacology
Abstract In contrast to the variable efficacy of 5-HT1A receptor full and partial agonists in animal models of anxiety, recent findings in our laboratory have revealed remarkably consistent anxiolytic-like effects for 5-HT1A receptor antagonists in the murine elevated plus-maze paradigm. In the present study, ethological techniques were used directly to compare the plus-maze profiles of three novel ligands varying in intrinsic efficacy at 5-HT1A receptors: LY293284 (full agonist; 0.01–0.3 mg… 
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