Comparative effects of nacre water-soluble matrix and dexamethasone on the alkaline phosphatase activity of MRC-5 fibroblasts.

@article{Almeida2001ComparativeEO,
  title={Comparative effects of nacre water-soluble matrix and dexamethasone on the alkaline phosphatase activity of MRC-5 fibroblasts.},
  author={Maria Jos{\'e} B. M. de Almeida and Lorena Pereira and Christian Milet and Josiane Haigle and Mario M. Barbosa and Evelyne Lopez},
  journal={Journal of biomedical materials research},
  year={2001},
  volume={57 2},
  pages={306-12}
}
In this study we demonstrate, for the first time, that dexamethasone and BMP-2 stimulated alkaline phosphatase (ALP) activity in MRC-5 fibroblasts, a cell line derived from human fetal lung. Previously we reported that the water-soluble matrix (WSM) of nacre obtained from the inner shell layer of the oyster Pinctada maxima, promoted an increase in ALP activity that was dose-dependent. In this work, we show that the effect of WSM is also time-dependent. As a comparison, the effect of WSM was… CONTINUE READING

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