Comparative effects of methamphetamine and nicotine on the striatal [(11)C]raclopride binding in unanesthetized monkeys.

@article{Tsukada2002ComparativeEO,
  title={Comparative effects of methamphetamine and nicotine on the striatal [(11)C]raclopride binding in unanesthetized monkeys.},
  author={Hideo Tsukada and Katsumasa Miyasato and Takeharu Kakiuchi and Shingo Nishiyama and Norihiro Harada and Edward F. Domino},
  journal={Synapse},
  year={2002},
  volume={45 4},
  pages={207-12}
}
Although a very large literature exists on the in vitro, ex vivo, and in vivo effects of nicotine on dopamine release in rodents, similar data in primates are scant. This study was initiated to compare methamphetamine to nicotine given i.v. to normal unanesthetized monkeys using positron emission tomography (PET) techniques. Release of dopamine in the striatum using [(11)C]raclopride was determined indirectly in four nicotine-naïve adult Macaca mulatta monkeys under conscious and isoflurane… CONTINUE READING
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