Comparative effects of etomidate and its fluoro analogue, R 8110 on testicular, adrenal and ovarian steroid biosynthesis.

@article{Coster1988ComparativeEO,
  title={Comparative effects of etomidate and its fluoro analogue, R 8110 on testicular, adrenal and ovarian steroid biosynthesis.},
  author={R. De Coster and W. Wouters and D. Beerens and C. Haelterman and R. Doolaege and N. Goeminne and M. Krekels},
  journal={Journal of veterinary pharmacology and therapeutics},
  year={1988},
  volume={11 4},
  pages={
          345-53
        }
}
  • R. De Coster, W. Wouters, +4 authors M. Krekels
  • Published 1988
  • Biology, Medicine
  • Journal of veterinary pharmacology and therapeutics
  • The effects, of etomidate and of its fluoro analogue, R 8110, on adrenal, testicular and ovarian steroid biosynthesis were compared using cultures of guinea-pig adrenal, rat adrenal capsular, rat testicular and rat ovarian granulosa cells. At a concentration of 100 nM, etomidate inhibited the adrenal 11-hydroxylation of glucocorticoid and mineralocorticoid biosyntheses, producing a decrease in cortisol and corticosterone and an accumulation of 11-deoxycortisol and 11-deoxycorticosterone in… CONTINUE READING
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