Comparative effects of d-amphetamine, l-amphetamine and methylphenidate on mood in man

@article{Smith2004ComparativeEO,
  title={Comparative effects of d-amphetamine, l-amphetamine and methylphenidate on mood in man},
  author={Robert C. Smith and John M. Davis},
  journal={Psychopharmacology},
  year={2004},
  volume={53},
  pages={1-12}
}
The comparative effects of d-amphetamine, l-amphetamine, and methylphenidate were assessed in 16 normal subjects, using a double-blind, crossover placebo-controlled design. Within the dose range tested, the efficacy ratio of d-amphetamine: l-amphetamine was about 2:1, and graphic presentation of dose response scores indicated a relatively small difference in potency between the amphetamine isomers. Methylphenidate was intermediate in efficacy between d-amphetamine and l-amphetamine. The… 

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References

SHOWING 1-10 OF 40 REFERENCES

Comparative Psychotomimetic Effects of Stereoisomers of Amphetamine

TLDR
Findings with regard to stereotypy suggested that dopaminergic mechanisms were largely involved in the induction of behavioural stereotypy, but that noradrenergic mechanisms might also contribute since the potency of d to l-amphetamine was found to be between 1 and 2 to 1, not 1 to 1 as might be expected if only non-stereospecific mechanisms were involved.

D & L amphetamine stereoisomers: comparative potencies in affecting the firing of central dopaminergic and noradrenergic neurons.

TLDR
It is suggested that l-amphetamine, at low doses, has a preferential effect on noradrenergic as compared to dopaminergic neurons, when combined with recent biochemical studies by other authors.

A Pilot Study of Pathogenic Mechanisms in Amphetamine Psychosis Utilizing Differential Effects of D and L Amphetamine

This preliminary investigation is, to a great extent, based on the prior work of two investigators, Griffith (12, 13) who has demonstrated the safety and feasibility of inducing amphetamine psychoses

Attenuation of the euphoriant and activating effects of d- and l-amphetamine by lithium carbonate treatment

TLDR
The possibility of lithium carbonate use as an adjunct in the treatment of amphetamine addiction is raised, with a 4.3-fold increase in rated euphoria and activation following 30 mg d-amphetamine in a replicated dose, double blind study.

Physiologic, subjective, and behavioral effects of amphetamine, methamphetamine, ephedrine, phenmetrazine, and methylphenidate in man

TLDR
This study suggests that it is unlikely that these central actions in man are a consequence of the release of norepinephrine in the brain, and suggests that these five agents share a common mode of central action.

EFFECTS OF URINARY pH ON AMPHETAMINE METABOLISM

TLDR
There are at least two major pathways for the metabolism of amphetamine, one involving p -hydroxylation and the other involving deamination, and the two pathways are about equally important in the dog.

Pharmacokinetic studies with amphetamines-relationship to neuropsychiatric disorders

TLDR
The intensity of the psychosis in patients having an alkaline urine appeared to be dependent on the metabolite levels rather than on the plasma levels of unchanged drug, and it was found that this metabolite was eliminated slower than the parent compound.

Methylphenidate, dextroamphetamine, and levamfetamine. Effects on schizophrenic symptoms.

TLDR
Findings augment a body of information suggesting that dopamine and norepinephrine may play a role in the activation of schizophrenic symptoms, and indicate complexities that remain to be resolved with methylphenidate.