Comparative effects of captopril and l-carnitine on blood pressure and antioxidant enzyme gene expression in the heart of spontaneously hypertensive rats.

@article{MiguelCarrasco2010ComparativeEO,
  title={Comparative effects of captopril and l-carnitine on blood pressure and antioxidant enzyme gene expression in the heart of spontaneously hypertensive rats.},
  author={Jos{\'e} Luis Miguel-Carrasco and Mar{\'i}a T. Monserrat and Alfonso Mate and Carmen Mar{\'i}a V{\'a}zquez},
  journal={European journal of pharmacology},
  year={2010},
  volume={632 1-3},
  pages={
          65-72
        }
}
It has been shown that oxidative stress is involved in the pathogenesis of arterial hypertension. The aim of this work was to study and compare the molecular mechanisms of the antioxidant properties of l-carnitine and captopril in spontaneously hypertensive rats (SHR). Antioxidant enzyme activity/regulation (glutathione peroxidase, glutathione reductase and superoxide dismutase) was measured in the erythrocytes and hearts of SHR. The molecular expression of endothelial nitric oxide synthase… CONTINUE READING
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