Comparative effects of bepridil, its quaternary derivative CERM 11888 and verapamil on caffeine‐induced contracture in ferret hearts

@article{Leboeuf1989ComparativeEO,
  title={Comparative effects of bepridil, its quaternary derivative CERM 11888 and verapamil on caffeine‐induced contracture in ferret hearts},
  author={J. Leboeuf and C. L{\'e}oty and J. Lamar and R. Massingham},
  journal={British Journal of Pharmacology},
  year={1989},
  volume={98}
}
  • J. Leboeuf, C. Léoty, +1 author R. Massingham
  • Published 1989
  • Chemistry, Medicine
  • British Journal of Pharmacology
  • 1 The effects of bepridil, its quaternary derivative: CERM 11888 (methyl‐pyrrolidinium bromide) (10−7‐10−5 M), and verapamil (10−7‐10−6 M) were compared on caffeine‐induced contracture of isolated ventricular trabeculae of the ferret. 2 Bepridil diminished the amplitude of contracture in a concentration‐dependent fashion, and this effect was significantly different from that of CERM 11888 which, like verapamil, only reduced the amplitude at the highest concentration used. 3 Bepridil (10−6 M… CONTINUE READING
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