Comparative effects of PEG-containing liposomal formulations on in vivo pharmacokinetics of streptokinase.

@article{Jin2015ComparativeEO,
  title={Comparative effects of PEG-containing liposomal formulations on in vivo pharmacokinetics of streptokinase.},
  author={Su-Eon Jin and In-Sook Kim and C K Kim},
  journal={Archives of pharmacal research},
  year={2015},
  volume={38 10},
  pages={1822-9}
}
Streptokinase (SK) is an effective thrombolytic agent, but it has a short half-life due to its rapid elimination from the body. In this study, we prepared and evaluated polyethyleneglycol (PEG)-based liposomal formulations (PEG-liposomes) containing SK with a view toward prolonging its circulatory half-life. SK-bearing liposomes (SK-liposomes) were prepared using freeze-thaw method after film hydration and extrusion techniques, composed of phosphatidylcholine [egg phosphatidylcholine (EPC… CONTINUE READING

References

Publications referenced by this paper.
Showing 1-10 of 27 references

Similar Papers

Loading similar papers…