Comparative effects of DL, D and L-3-pyridylalanine on serotonin concentration and tryptophan-serotonin metabolizing enzymes.

@article{Shimeno1984ComparativeEO,
  title={Comparative effects of DL, D and L-3-pyridylalanine on serotonin concentration and tryptophan-serotonin metabolizing enzymes.},
  author={Hiroshi Shimeno and Y Fukumoto and M Fuji and Atsuo Nagamatsu},
  journal={Chemical \& pharmaceutical bulletin},
  year={1984},
  volume={32 9},
  pages={
          3620-5
        }
}
The administration of DL-3-pyridylalanine (DL-3-PA, DL-α-amino-3-pyridinepropanoic acid) or L-3-PA significantly increased brain serotonin (5-HT) concentration without affecting the other tissue 5-HT concentrations in male Wistar rats. The increase in brain 5-HT upon the administration of DL or L-3-PA was maintained for a long time (at least 96h). DL and L-3-PA decreased tryptophan pyrrolase activity in the liver and increased free tryptophan concentration in the serum. These effects found in… 
2 Citations
Synthesis of 3-(3-pyridyl)- and 3-(3-benzo[b]thienyl)-D-alanine.
The DL-arylamino acid ethyl ester derivatives of beta-(3-pyridyl)-DL-alanine, and beta-(3-benzo[b]thienyl)-DL-alanine were synthesized by diethyl acetamidomalonate condensation with the respective
Synthesis, crystal structure and molecular conformation of Nalpha-Boc-L-leucyl-(Z)-beta-(3-pyridyl)-alpha,beta- dehydroalanyl-L-leucine methyl ester.
TLDR
X-ray crystallographic analysis revealed that the peptide 1 adopts an extended conformation, which is similar to that of a Delta(Z)Phe analog, Boc-Leu-Delta(Z)-beta-(3-pyridyl)-alpha,beta-dehydroalanine (Delta( Z)3Pal) residue, which was synthesized via Erlenmeyer azlactone method.