Comparative effectiveness of different antihypertensive agents in kidney transplantation: a systematic review and meta-analysis.
@article{Pisano2019ComparativeEO, title={Comparative effectiveness of different antihypertensive agents in kidney transplantation: a systematic review and meta-analysis.}, author={Anna Rita Pisano and Davide Bolignano and Francesca Romana Mallamaci and Graziella D’Arrigo and Jean-Michel Halimi and Alexandre Persu and Gr{\'e}goire Wuerzner and Pantelis A. Sarafidis and Bruno Watschinger and Michel Burnier and Carmine Zoccali}, journal={Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association}, year={2019} }
BACKGROUND
We conducted a systematic review and meta-analysis to compare benefits and harms of different antihypertensive drug classes in kidney transplant recipients, as post-transplant hypertension (HTN) associates with increased cardiovascular (CV) morbidity and mortality.
METHODS
The Ovid-MEDLINE, PubMed and CENTRAL databases were searched for randomized controlled trials (RCTs) comparing all main antihypertensive agents versus placebo/no treatment, routine treatment.
RESULTS
The search…
22 Citations
OP-NDTJ190093 1..10
- Medicine
- 2019
CCBs could be the preferred first-step antihypertensive agents in kidney transplant patients, as they improve graft function and reduce graft loss.
Adverse Effects of Angiotensin-Converting Enzyme Inhibitors in Humans: A Systematic Review and Meta-Analysis of 378 Randomized Controlled Trials
- MedicineInternational journal of environmental research and public health
- 2022
Background: Although angiotensin-converting enzyme (ACE) inhibitors are among the most-prescribed medications in the world, the extent to which they increase the risk of adverse effects remains…
Antihypertensive Treatment in Kidney Transplant Recipients—A Current Single Center Experience
- MedicineJournal of clinical medicine
- 2020
In addition to the well-known risk factors of cold ischemic time and acute rejection episodes, the number of antihypertensive drugs after one year, which reflects the severity of hypertension, is a strong predictor of unfavorable allograft survival.
Assessment of hypertension in kidney transplantation by ambulatory blood pressure monitoring: a systematic review and meta-analysis
- MedicineClinical Kidney Journal
- 2021
Comparison of OBP versus ABP measurements disclosed a high proportion of MHT, uncontrolled HTN and, to a lesser extent, WCH in KTRs, suggesting that HTN is not adequately diagnosed and controlled by OBP recordings in this population.
Should ACE inhibitors or calcium channel blockers be used for post-transplant hypertension?
- MedicinePediatric Nephrology
- 2020
The results of the most current meta-analyses recommend that due to their positive effects on graft function and survival, along with their lack of negative effects on serum potassium, CCBs could be the preferred first-line antihypertensive agent in renal transplant recipients, however, anti Hypertensive therapy should be individually tailored based on other factors.
Update on Treatment of Hypertension After Renal Transplantation
- MedicineCurrent Hypertension Reports
- 2021
Recommendations about BP targets in adult renal transplant recipients are coming from a post hoc analysis of a large randomized trial with another primary endpoint, and unless convincing studies on treatment of hypertension after renal transplantation are available, the ESC/ESH Guidelines 2018 should apply.
Arterial hypertension in kidney transplantation: huge importance, but few answers.
- MedicineJornal brasileiro de nefrologia : 'orgao oficial de Sociedades Brasileira e Latino-Americana de Nefrologia
- 2022
The aim of the present study was to review the issue of hypertension in RTX, addressing its multifactorial pathophysiology and demonstrating the importance of ABPM as a tool for monitoring BP in patients with discrepant blood pressure values.
Hypertension in kidney transplantation: a consensus statement of the ‘hypertension and the kidney’ working group of the European Society of Hypertension
- MedicineJournal of hypertension
- 2021
The current transplant guidelines, which recommend only office BP assessments for risk stratification in kidney transplant patients should be reconsidered, given the presence of white-coat hypertension and masked hypertension in this population and the better prediction of adverse outcomes by 24-h ambulatory BP monitoring as indicated in recent systematic reviews.
Role of hypertension in kidney transplant recipients
- Medicine, BiologyJournal of Human Hypertension
- 2021
Based on the relevant guidelines in the general population, lifestyle modifications should probably be applied as the first step of hypertension management in kidney transplant recipients.
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