Comparative effect of the thiols dithiothreitol, cysteamine and WR-151326 on survival and on the induction of DNA damage in cultured Chinese hamster ovary cells exposed to gamma-radiation.

@article{Murray1990ComparativeEO,
  title={Comparative effect of the thiols dithiothreitol, cysteamine and WR-151326 on survival and on the induction of DNA damage in cultured Chinese hamster ovary cells exposed to gamma-radiation.},
  author={D. Murray and A. Prager and S. C. Vanankeren and E. Altschuler and M. S. Kerr and N. Terry and L. Milas},
  journal={International journal of radiation biology},
  year={1990},
  volume={58 1},
  pages={
          71-91
        }
}
We compared the ability of three thiols--dithiothreitol (DTT), cysteamine and WR-151326--to protect aerated Chinese hamster ovary cells from the lethal and DNA-damaging effects of gamma-radiation. These results were compared with earlier measurements for WR-1065 and WR-255591. The time-course and the concentration dependence of protection against cell killing was determined after 10 Gy of gamma-rays. The aminothiols cysteamine and WR-151326 protected at much lower extracellular concentrations… Expand
Influence of intracellular thiol and polyamine levels on radioprotection by aminothiols.
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Radioprotection of cultured Chinese hamster ovary cells by WR-255591.
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