Comparative effect of protein binding on the killing activities of teicoplanin and vancomycin.

  title={Comparative effect of protein binding on the killing activities of teicoplanin and vancomycin.},
  author={E. Bailey and M. Rybak and G. Kaatz},
  journal={Antimicrobial Agents and Chemotherapy},
  pages={1089 - 1092}
The effect of protein binding on the activity of teicoplanin against Staphylococcus aureus was evaluated. Bactericidal rates of teicoplanin in cation-supplemented Mueller-Hinton broth (SMHB) and in a 1:1 mixture of pooled human serum and cation-supplemented Mueller-Hinton broth (PHS-SMHB) were compared with those of vancomycin. Eight concentrations of each drug ranging from 15 to 150 micrograms/ml were studied in two series which correspond to the concentrations in serum achieved with low- (6… Expand
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