Comparative effect of berberine and its derivative 8-cetylberberine on attenuating atherosclerosis in ApoE-/- mice.

@article{Feng2017ComparativeEO,
  title={Comparative effect of berberine and its derivative 8-cetylberberine on attenuating atherosclerosis in ApoE-/- mice.},
  author={Min Feng and Zongyao Zou and Xia D Zhou and Yinran Hu and Hang Ma and Yubo Xiao and Xuegang Li and Xiaoli Ye},
  journal={International immunopharmacology},
  year={2017},
  volume={43},
  pages={
          195-202
        }
}
Berberine (BBR), one of the main bioactive compounds in Rhizoma coptidis, has multiple pharmacological activities. It has been reported that 8-cetylberberine (8-BBR-C16) has increased anti-microbial property in vivo and a higher bioavailability in hamsters. Therefore, in the present study, we used apolipoprotein E-deficient mice (ApoE-/-) as an atherosclerosis model to investigate the anti-atherosclerosis effects of 8-BBR-C16. After 12weeks of treatment, the atherosclerotic plaque area of the… CONTINUE READING

References

Publications referenced by this paper.
SHOWING 1-10 OF 41 REFERENCES

Plasma concentration of interleukin-6 and the risk of future myocardial infarction among apparently healthy men, Circulation

P. M. Ridker
  • 2000
VIEW 11 EXCERPTS
HIGHLY INFLUENTIAL

IL-1 signaling in atherosclerosis: sibling rivalry

  • Nature Immunology
  • 2013
VIEW 14 EXCERPTS
HIGHLY INFLUENTIAL

Comparative study of pharmacokinetics and tissue distribution of 8cetylberberine and berberine in rats, Yao xue xue bao = Acta Pharmaceutica Sinica

Y. L. Hu
  • 2014
VIEW 3 EXCERPTS